Exon 2 of the MAN1A2-201, exon 1 of the TRDC-201, exon 4 of the TRDC-201, exon 3 of the AE000661.37-007, exon 5 of the DDI2-202, and exon 2 of the TRDV2-201 transcripts were all upregulated in PD patients after three years of the disease progression. The gene discussed is MAN1A2; the disease is Parkinson disease.