OPA1 and neurodegenerative disease: Disruptions in mitochondrial dynamics, often caused by mutations in MFN2 (OMIM #608507) or OPA1 (OMIM #605290), are associated with several neurodegenerative diseases and hereditary neuropathies, such as Charcot-Marie-Tooth disease type 2A (CMT2A, OMIM #609260) and autosomal dominant optic atrophy (ADOA, OMIM #165500).