PALM2AKAP2 and myocardial infarction: Intriguingly, AKAP2 plays dual roles in the heart depending on the cell type: in cardiomyocytes, AKAP2 scaffolds PKA and the transcriptional coactivator SRC-3, which leads to activation of estrogen receptor α and increased expression of pro-survival and pro-angiogenic genes (like BCL-2 and VEGFA); this is beneficial, helping cardiomyocytes resist apoptosis and indirectly reducing fibrosis after myocardial infarction [23].