These scaffolds have well-documented roles across multiple organ fibroses: for instance, α6β1 integrin mediates mechanosignaling in lung fibrosis, Cav1 links membrane tension to fibrogenic secretion in liver fibrosis, TKS5 drives matrix degradation in lung fibrosis, and TRPV4–PI3Kγ triggers myofibroblast differentiation in stiff lung tissue. This evidence concerns the gene SH3PXD2A and pulmonary fibrosis.