APP and Alzheimer disease: To test the efficacy of rhMG53 on enhancing plasma membrane repair in APP/PS1 mice, an AD mouse model which overexpress Aβ, we treated live whole brain slices from 6-month APP/PS1 mice, with no experimental intervention or 1 μM rhMG53 and compared the data to 6-month C57Bl/6 control mouse whole brain slices.