To investigate the signaling pathway through which OSGIN-1 regulates ferroptosis in ovarian cancer cells, Deng et al. (2025) searched the BioGRID protein–protein interaction database to identify ataxia-telangiectasia mutated (ATM), a serine/threonine kinase that phosphorylates AMPK to activate the AMPK signaling pathway, as a putative interacting partner of OSGIN-1. Here, OSGIN1 is linked to ovarian carcinoma.