Further exploring whether p53 regulates the physiological functions of OSGIN-1, Liu et al. (2014) did not observe a significant correlation between p53 mutations and OSGIN-1 expression in hepatocellular carcinoma tissue samples, indicating that p53 is involved in, but not necessary for, the pro-apoptotic function of OSGIN-1 [52]. Here, TP53 is linked to hepatocellular carcinoma.