Xie et al. applied a high dimensional approach to analyze associations between GLP-1 treatment and health outcomes in over 1.9 million persons over an average of 3.68 years based on data from the US Department of Veterans Affairs and found, in addition to gastrointestinal and other common symptoms, a significant increase in hypotension, joint pain, kidney stones, and nephrolithiasis [190]. The gene discussed is GLP1R; the disease is nephrolithiasis.