TYR and melanoma: The inhibitory effects of leaf-derived (LEVs) and stem-derived extracellular vesicles (SEVs) of Dendropanax morbifera on melanin production were examined by Lee and colleagues, and their data indicated that the aforementioned EVs reduced melanin content and tyrosinase (TYR) activity in the B16BL6 mouse melanoma cell line in a concentration-dependent manner.