In one of these studies, the effects of nanovesicles isolated from tangerine peel on hepatic steatosis associated with type 2 diabetes were investigated in a mutant diabetic mouse model, and the effects of nanovesicles on peroxisome proliferator-activated receptor alpha (PPAR-α), PGC1α, mitochondrial uncoupling protein 1 (UCP1), and PR domain-containing 16 (PRDM16) were analyzed. This evidence concerns the gene PRDM16 and type 2 diabetes mellitus.