GRM7 and major depressive disorder: In studies on models of complex behaviors, Novartis Grm7-/- and Grm7+/+ mice were also compared in the forced swim test, the tail suspension test (both believed to be suitable for the assessments of depression- and anxiety-like behaviors) and in four different behavioral tests, e.g., the light–dark box, the elevated plus maze, the staircase test, and the stress-induced hyperthermia test, in which the Grm7-/- mice showed anxiolytic-like behavior [42]—but see also [82].