As a step forward in the field of mGluR7 ligands, the recent identification, optimization, and characterization of a highly potent (EC(50) 7 nM), novel allosteric mGluR7 agonist, chromane CVN636, demonstrates exquisite selectivity for mGluR7 and efficacy in an in vivo rodent model of alcohol use disorder [71] supporting the first report which links Grm7 to alcohol drinking in a mouse model [11]. Here, GRM7 is linked to alcohol abuse.