TGR5 drives secretion of crucial metabolic hormones such as gastrin, glucagon, secretin, motilin, pancreatic polypeptide, cholecystokinin and glucagon-like peptide-1 and 2 (GLP-1/2), which respectively increases insulin sensitivity and release and regulates hepatic steatosis and gut growth and integrity [81,82]. The gene discussed is GCG; the disease is fatty liver disease.