NFKB1 and colorectal cancer: In colorectal cancer, mutations in the APC gene, a tumor suppressor and key regulator of the Wnt pathway, microsatellite instability (MSI) from mutations in mismatch repair genes MLH1 and MSH2, and activation of the NF-κB pathway and COX-2 expression associated with chronic inflammation are more prevalent [13,14,15].