Wogonin further highlights the versatility of skullcap flavonoids by inducing autophagy and apoptosis in SW480 CRC cells, mediated byG2/M phase arrest and the STAT3 and PI3K/Akt pathways suppression, while in lung cancer models, it suppresses A549 and H460 cell growth and metastasis by downregulating MMP1 and modulating the PI3K/Akt pathway [146,147]. This evidence concerns the gene STAT3 and colorectal carcinoma.