For example, an ethanol extract of Glycyrrhiza glabra induces apoptosis in HT29 cells via HSP90 downregulation [134], while total saponins extracted from Astragalus membranaceus root modulate mTOR and COX-2 signaling, reducing VEGF levels and suppressing angiogenesis in HCT116 colon cancer cells [135]. This evidence concerns the gene MTOR and malignant colon neoplasm.