In addition, micro-RNA-1 plays a role in the regulation of Cx43 function and localization in cardiac hypertrophy in mice [61], in the protection from ischemic damage by telmisartan in rat myocardium [62] and in mice iPSC-CMs (induced pluripotent stem cell-derived cardiomyocytes) subjected to rapid pacing [78]. The gene discussed is GJA1; the disease is cardiac hypertrophy.