The present study also aimed to verify the differential expression of EGFR, TRKB, KRAS, and HIF-1α, involved in the tumor malignancy process in the subpopulations of TSCs and non-TSCs, and to verify whether the expression of these structures is related to the phenotype of TSCs, as well as the response of HNC to treatment. This evidence concerns the gene EGFR and neoplasm.