Injured podocytes often exhibit overexpression of the deubiquitinating enzyme ubiquitin C-terminal hydrolase L1 (UCH-L1), causing impaired proteasomal degradation and exacerbating glomerular damage in conditions like membranous nephropathy and focal segmental glomerulosclerosis (FSGS) [36]. The gene discussed is UCHL1; the disease is focal segmental glomerulosclerosis.