Proteins of the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family are a group of PRR, and some of them, including NLRP3, NLRP6 NLRC1, NLRC2, NLRC5, and NLRP12, promote inflammation in obesity [14,15,16]. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.