NFKB1 and colorectal carcinoma: Table 1 summarizes the discovered mechanisms of the synergistic effects of curcumin with 5-FU-based therapies in different in vitro and in vivo models of CRC, including apoptosis inhibition, the dysregulation of survival pathways associated with inflammation such as NFκB and COX2, and the inhibition of stemness and EMT properties.