NFKB1 and cancer: The mechanism of action of curcumin against cancer cells involves the negative regulation of NF-κB, EGFR, and PI3K/AKT signaling pathways that lead to the diminished activity and expression of proteins involved in anti-apoptotic processes, such as Bcl-2 and Bcl-xL, while inducing Bax, caspase-3, and p53 pro-apoptotic molecules.