TP53 and colorectal carcinoma: The dual role of autophagy in response to chemotherapies appears to be dependent on the origin of the neoplasia and used drugs, as observed in p53-null CRC cell lines, in which irinotecan treatment increases the autophagy favoring resistance to tumoral cell death, while data observed in hepatocellular carcinoma, colon, and pancreatic cancer showed that the restoration of autophagy favored 5-FU activity [114,115].