Abbreviations: ACE: Angiotensin Converting Enzyme; ARBs: Angiotensin Receptor Blockers; MASLD: metabolic dysfunction-associated steatotic liver disease; NASH: nonalcoholic steatohepatitis; MASH: metabolic dysfunction-associated steatohepatitis; HFrEF: heart failure with reduced ejection fraction; GLP-1: Glucagon-like Peptide-1; GIP: Glucose-Dependent Insulinotropic Peptide; PCSK9i: proprotein convertase subtilisin/kexin type 9 inhibitors. The gene discussed is PCSK9; the disease is metabolic dysfunction-associated steatohepatitis.