Four main cellular states were identified within the different malignant tumor cells, neural-progenitor-like, oligodendrocyte-progenitor-like, astrocyte-like, and mesenchymal-like, which exist in different proportions in each tumor and are characterized by genetic aberrations in CDK4, PDGFRA, EGFR, and NF1. This evidence concerns the gene CDK4 and neoplasm.