Through the use of LPS-treated and Nrf2 KO mice, it examined (1) the effects of Nrf2 activation on BDNF and its repressors, (2) Nrf2-mediated Bdnf transcription using luciferase and ChIP assays, (3) Nrf2-BDNF crosstalk in depression-like behaviors, and (4) their roles in resilience vs. susceptibility in mice exposed to chronic social defeat stress (CSDS) [103]. Here, BDNF is linked to major depressive disorder.