The equally effective ACE inhibitor and AT1R blocker treatment in our T1D model indicate that extracellular ACE has an important role in the activation of local, cardiac RAS and the production of ATII in STZ-induced diabetes since the applied ACE inhibitor cannot enter cells and affect intracellular ATII production in the cardiomyocytes. Here, AGTR1 is linked to type 1 diabetes mellitus.