Variants were additionally found in genes linked to nephrogenic diabetes insipidus type 1 (AVPR2), the SLC2A2 gene encoding the GLUT2 protein, which plays a key role in glucose metabolism, and the MAPK8IP1 gene encoding a regulator of pancreatic beta-cell function (Table 4). This evidence concerns the gene SLC2A2 and nephrogenic diabetes insipidus.