They identified 30 rare variants potentially associated with obesity in 36 of the 243 children across 15 candidate genes (LEP, LEPR, POMC, MC3R, MC4R, MRAP2, SH2B1, BDNF, NTRK2, DYRK1B, SIM1, GNAS, ADCY3, RAI1, and BBS2). This evidence concerns the gene RAI1 and obesity due to melanocortin 4 receptor deficiency.