Furthermore, cHL tumour cells show deregulations of specific transcription factors (TFs), including aberrantly activated NFkB factors and AP-1 factor JUNB [1,5], in addition to the aberrant downregulation of B-cell-specific TFs, including basic helix-loop-helix factor TCF3 and homeodomain factor PAX5 [1]. The gene discussed is JUNB; the disease is neoplasm.