The crucial role played by TRPV4 in pathological remodeling has been recently confirmed by Yáñez-Bibe and coworkers, who showed that the genetic deletion of TRPV4 prevented adverse fibrotic remodeling in two different mouse models of HF (i.e., TAC- and isoproterenol-induced HF) [167]. Here, TRPV4 is linked to hydrops fetalis.