TLR7 (TLR7 fold change = 5.40) induces the production of proinflammatory cytokines and interferon type I. It recognizes intracellular single-stranded RNA and promotes autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), while its effects are MYD88-dependent (MYD88 fold change = 6.56) [39]. This evidence concerns the gene MYD88 and rheumatoid arthritis.