↑ Mitochondrial respiration, ↓ cardiac remodeling, ↑ NOS1 activity, ↑ cardiomyocyte contractility, ↑ systolic function, ↑ diastolic function, ↓ 12,13-diHOME in heart disease, ↑ glucose tolerance, ↑ fatty acid uptake, ↑ ejection fraction. Here, NOS1 is linked to heart disorder.