Another study found that variants of PON1 (encoding paraoxonase-1, a hydrolase involved in low-density lipoprotein (LDL) metabolism), IGF2 (encoding insulin-like growth factor 2) had higher rates of homozygosity in a cohort of 72 patients with PCOS compared to 42 controls [23]. This evidence concerns the gene IGF2 and polycystic ovary syndrome.