BCR and diffuse large B-cell lymphoma: More recently, metabolic signatures uncovered distinct metabolic DLBCL subsets [12], including the OxPhos DLBCL subset that is characterized by a non-functional BCR and an increased mitochondrial metabolism that is required for this DLBCL subset survival, and the BCR subset that presents an upregulation of genes encoding BCR signaling components and enzymes associated with glycolysis [12,13,14].