The data from our systematic review showed a notable rise in CTLA-4 epithelial expression in adenomas with LGD, HGD, and CRC when compared to normal specimens [80], whereas the abundance of CTLA-4+ TILs significantly favored adenomas with LGD over normal mucosa, HGD, and adenocarcinoma cases. The gene discussed is CTLA4; the disease is colorectal carcinoma.