Low-grade dysplasia (LGD) levels of FOXP3+ regulatory T cells were found to be higher in sporadic cases rather than FAP cases [61,79], implying that the host has a better tolerance for hereditary lesions than sporadic ones, thus possibly facilitating the earlier occurrence of adenomas and carcinomas in FAP patients. This evidence concerns the gene FOXP3 and Familial adenomatous polyposis.