HER2E-mRNA subtype/HER2-positive tumors presented increased expression of HER1/EGFR, p-HER1, HER2, p-HER2, p-SRC and p-S6, whereas these features were not obvious in luminal-mRNA subtype/HER2-positive tumors; in contrast, luminal-mRNA subtype/HER2-positive tumors presented increased expression of protein markers associated with luminal cancer, such as GATA3, BCL2 and ESR1. The gene discussed is EGFR; the disease is cancer.