For example, Kikuchi et al. [34] identified 3621 proteins via unlabeled shotgun proteomic analysis of non-small-cell lung cancer 21 and reported that the PAK 2 protein was significantly upregulated in non-small-cell lung cancer samples, which suggested that PAK 2 was a potential biomarker and a drug target. This evidence concerns the gene PAK2 and non-small cell lung carcinoma.