UR3 strain, isolated and purified from the Red Sea sponge, Hyrtios sp., contains a plethora of metabolites with AKT1, ESR1, and EGFR tyrosine kinase inhibitory potential and a powerful activity against colorectal (CACO2), BC (MCF7), and HCC (HEPG2) cell lines [193]. The gene discussed is ESR1; the disease is breast cancer.