Results: Among glioblastomas (GBMs, WHO grade 4) originating from the two cortical regions, there was a significant difference in the human Telomerase Reverse Transcriptase (TERT) promoter mutation rate, while no difference was observed in O6-Methylguanine-DNA Methyltransferase (MGMT) promoter methylation status. Here, MGMT is linked to glioblastoma.