IGHE and urticaria: MC degranulation independently from the IgE/FceRI axis is described for some types of pathogen-mediated MC activations, and physical stimuli, as well physical urticaria, part of the adverse reactions to contrast media or cationic groups of neuromuscular blocking agents, morphin, fluroquinolone and vancomycin, autosominal dominant vibratory urticaria, hereditary alfa-tryptasemia, mastocyotosis, and the MC activation syndrome [50,51,52,53,54].