Upon subsequent exposure to multivalent allergenic antigens, these cells degranulate and activate due to crosslinking; the immediate effects that follow include vasodilation, bronchoconstriction, and allergic inflammation, which are characteristic of conditions such as allergic rhinitis and asthma, food allergies, and allergic responses to venom or medications, as well as IgE-mediated types of urticaria-angiedema and anaphylaxis [49]. The gene discussed is IGHE; the disease is urticaria.