CRH and dermatitis: Differently, acute stress in the absence of previous sensitization, through SP, NK-1 receptor, and nerve growth factor, may induce neurogenic skin inflammation in mice [34]; moreover, the activation from the stress of a homologous hypothalamic–pituitary–adrenal (HPA) axis in the skin determines the exacerbation of many dermatological diseases through the release of proinflammatory hormones, neuropeptides, and neurotrophins, in particular, through MCs’ stimulation by corticotropin-releasing factor (CRF) [2,35,36,37].