Unlike the previous reports of MPGN patients with FH-autoantibodies, in this IC-MPGN patient, the autoantibodies showed binding on both the N- and C-termini of FH, which together with the various isotypes identified (Supplementary Figure S3C,E) imply oligoclonal origin of the autoantibodies. The gene discussed is FH; the disease is primary membranoproliferative glomerulonephritis.