Among the various risk factors contributing to CVD development, familial hypercholesterolemia (FH) is of particular interest due to its solid genetic basis LDL receptor (LDL-R), apolipoprotein B-100 (APOB), and protein convertase subtilisin/kexin type 9 (PCSK9). The gene discussed is PCSK9; the disease is familial hyperaldosteronism.