In colon cancer, the expression levels of NOTCH1, NOTCH2, and NOTCH3 were found to be increased, whereas the expression of ATOH1 was decreased in CRC [131], Given that Notch signaling prevents the final differentiation of goblet cells within the colorectal mucosa, it plays an oncogenic role in CRC. The gene discussed is NOTCH1; the disease is colorectal carcinoma.