In colon cancer, the expression levels of NOTCH1, NOTCH2, and NOTCH3 were found to be increased, whereas the expression of ATOH1 was decreased in CRC [131], Given that Notch signaling prevents the final differentiation of goblet cells within the colorectal mucosa, it plays an oncogenic role in CRC. This evidence concerns the gene ATOH1 and colorectal carcinoma.