NOS2 and obesity due to melanocortin 4 receptor deficiency: MO seed oil extract (800 mg/kg b.w.)and lycopene (LYC) significantly improved high-fat diet (HFD)-induced metabolic disturbances in Sprague–Dawley rats by enhancing antioxidant enzymes, reducing lipid peroxidation and inflammatory cytokines, and decreasing iNOS (inducible nitric oxide synthase) protein expression, demonstrating anti-obesity potential [166].