Novel therapies, including sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) agonists, and mineralocorticoid receptor antagonists (MRAs) shown to be effective in conditions such as type 2 diabetes (T2DM), heart failure, and CKD, and it is likely these drugs target shared pathways implicated in metabolic, cardiovascular, and renal disease. This evidence concerns the gene SLC5A2 and kidney disorder.