A high level of three proteins (SHBG, SCUEB3 and TNFSF22) and a low level of seven proteins (ATP1B2, LY75, HDGFRP3, ECM2, APOC1, ATXN3, CLSTN2) are risk factors for ALS. The gene discussed is ECM2; the disease is amyotrophic lateral sclerosis.