We conducted MR analysis between pQTLs of 905 proteins and ALS, the cutoff of P value was adjusted by the Bonferroni method (0.05/905 = 5.5249 × 10−5), and 21 significant proteins were found (SHBG, SCUBE3, ATP1B2, LY75, HDGFRP3, ECM1, TNFSF12, APOC1, ATXN3, CLSTN2, NT5C3L, TIMD4, NID1, TCN2, LCT, IL1RL1, SERPING1, UGT1A6, HGFAC, PLA2R1, DECR2) (Figure 2A). The gene discussed is HDGFL3; the disease is amyotrophic lateral sclerosis.