We conducted MR analysis between pQTLs of 905 proteins and ALS, the cutoff of P value was adjusted by the Bonferroni method (0.05/905 = 5.5249 × 10−5), and 21 significant proteins were found (SHBG, SCUBE3, ATP1B2, LY75, HDGFRP3, ECM1, TNFSF12, APOC1, ATXN3, CLSTN2, NT5C3L, TIMD4, NID1, TCN2, LCT, IL1RL1, SERPING1, UGT1A6, HGFAC, PLA2R1, DECR2) (Figure 2A). This evidence concerns the gene SHBG and amyotrophic lateral sclerosis.