In 2019, it has been reported that in AML with an activating c-Kit N822K mutation, the mutant is active on the Golgi, leading to an activation of Akt, MAPK, and STAT5 signaling, while the inactive/dephosphorylated c-Kit form is localized in the ER [37]. The gene discussed is KIT; the disease is acute myeloid leukemia.