The expression of lncRNA RP11-297P16.4 was positively related to MMP-2/9, suggesting that lncRNA RP11-297P16.4 might positively regulate the post-transcriptional expression of MMP-2 and MMP-9 in NSCLC cells in vitro (Figure 4). This evidence concerns the gene MMP9 and non-small cell lung carcinoma.