The incidence of genotypes of TLR9 rs5743836 (T1237C) SNP was as follows: the wild genotype (T/T) is expressed in (32.1%) of COPD patients, (66.7%) of the control group, (22.9%) of exacerbated COPD patients, and (41.7% of stable) COPD patients. This evidence concerns the gene TLR9 and chronic obstructive pulmonary disease.