Mainly involved in accelerated aerobic glycolysis supporting the increased cancer cell metabolic needs (Warburg effect), the glycolytic enzyme enolase-2 (also known as γ-enolase neuron-specific enolase) is upregulated in tumors including BC and lymph node metastases, with its major contribution to tumor progression including cell migration and invasion through actin cytoskeleton remodeling [53,54]. The gene discussed is HK1; the disease is neoplasm.