PD risk genes such as DJ-1, PINK1, PRKN, and LRRK2 share mitochondrial dysfunction, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a complex I inhibitor, induces parkinsonism, which is frequently used in PD mouse models. The gene discussed is PRKN; the disease is Parkinson disease.