ADIPOQ and Lipedema: While some of the abovementioned and cell-based studies implicate impaired adipogenesis in lipedema, 3D spheroids derived from adipose-derived stem cells from patients (n = 8; >85% stage 2–3) exhibited expression levels of adipogenic genes, in particular adiponectin, lipoprotein lipase, PPAR-γ, and glucose transporter type 4 that were similar to spheroids from healthy controls (n = 8; with lower BMI: 27.3 ± 1.0 vs. 30.4 ± 1.2 kg/m2 in controls) [41].