PF4 and Lipedema: A mass spectrometry analysis identified elevated levels of platelet factor 4 in exosomes isolated from the plasma of patients diagnosed with lipedema (n = 15; stage 1 (n = 4), stage 2 (n = 6), stage 3 (n = 5); BMI 36 ± 9 kg/m2) compared to the controls [83].