In addition, miR-34a has an inhibitory effect on NOTCH1, NOTCH2, and NOTCH4 expression in pancreatic ductal carcinoma [90], whereas, in colon carcinoma, its inhibition rescued the expression of NOTCH1, NOTCH2, and BCL2 [91]. This evidence concerns the gene NOTCH4 and pancreatic ductal adenocarcinoma.