In addition, using the insulin-producing rat insulinoma cell line INS1 as an example, MitoTimer was shown to be successful in screening libraries of thousands of small molecules to find compounds that stimulate basal mitophagy, which positively affects mitochondrial function, activity, and expression of Complex I, Complex II, and Complex III, which may mediate the improvement in insulin secretion in mouse pancreatic islets [22]. Here, INS is linked to pancreatic insulinoma.