Although the MitoTimer is a working tool for studying mitochondria in live cells and in real time, and there is ample evidence that tau protein dysfunction significantly affects mitochondrial function [23,24], we found no published studies using this biosensor to generate and study human neurodegenerative disease models based on differentiated iPSC derivatives in general and frontotemporal dementia with parkinsonism-17 in particular. The gene discussed is MAPT; the disease is neurodegenerative disease.