This study aims to investigate the possible role of inflammation in the telomere’s attrition and TE aberrations in T2D by testing the correlations of LTL, TE levels, and gene polymorphism with the levels of the inflammation biomarkers IL-6, IL-8, TREM-1, and uPAR and the IL6/IL8 ratio, with the consideration of age as a confounding factor. This evidence concerns the gene IL6 and type 2 diabetes mellitus.