Pathway and ontology analyses indicated that miR-15b, miR-26a, miR-301, miR-30b, and miR-30c participate in essential processes related to obesity, such as adipogenesis, fatty acid oxidation, mTOR (mechanistic target of rapamycin kinase) signaling, PPAR signaling, and Wnt signaling. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.