MT-ND1 and open-angle glaucoma: A recent study from North India identified pathogenic mtDNA variants in POAG patients, including m.3880G>A in ND1, m.4852T>A in ND2, and m.8250G>A in COX2, associated with reduced cytochrome c oxidase activity and increased oxidative stress, contributing to disease severity and accounting for 32% of POAG patients harboring these changes [84].