Among the many mtDNA pathogenic variants reported in LHON (see Table 1), three primary mtDNA point pathogenic variants (m.3460G>A in MT-ND1, m.11778G>A in MT-ND4, and m.14484T>C in MT-ND6) account for approximately 90% of LHON cases globally, with m.11778G>A accounting for 70% of LHON cases and m.3460G>A being the least prevalent [11]. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.