Another study involving 206 CRC patients and 353 healthy controls demonstrated that individuals with the APOE ε2/ε3 genotype were at a higher risk of developing CRC compared to those with the most common ε3/ε3 genotype, while male patients with the ε2/ε3 genotype exhibited a greater prevalence of advanced CRC (Duke stages C&D) [166]; thus far, there have not been any strong signals from GWAS of CRC [167]. The gene discussed is APOE; the disease is colorectal carcinoma.