Increased levels of ApoE potentially induce senescence in neutrophils, through ApoE-mediated activation of triggering receptor expressed on myeloid cells 2 (TREM2), which has recently been associated with a worse outcome in ovarian cancer patients [186] but is also of interest in AD where it is a recognized risk gene and where its role may also have an immune-related function [188,189]. This evidence concerns the gene APOE and Alzheimer disease.