The T-allele of the rs1360780 SNP is considered a risk variant because it determines a high induction of FKBP5, delaying negative feedback and increasing GR resistance, which leads to states of relative hypercortisolemia and brain morphofunctional changes, especially in regions sensitive to glucocorticoid activity and during specific periods of neurodevelopment. This evidence concerns the gene NR3C1 and adrenal gland hyperfunction.